There is an important microbial ecosystem in the gut that helps maintain physical and mental health, protects us from pathogens, helps us digest food and forms vitamins in the body. If the ecosystem is disrupted, it may cause infections, inflammation or allergies.
But scientists believe that eating foods that contain certain microorganisms can be effective against certain diseases and make us healthier. This kind of food is called probiotics, it will be combined with the microbes in the human body to play a synergistic role.
Dr. Bejit Ideas, president of the Japanese Society of Anti-aging Nutrition, and Lee Yuan Kun, associate professor of Microbiology at the Yang Luling School of Medicine, National University of Singapore, were attracted by the interaction between microorganisms and probiotics, and tried many ways to explore the relationship between microorganisms and human health.
Over the years, Dr. Ideas has devoted himself to studying the microflora in the gut of centenarians in Okinawa, Japan, in an attempt to explore its uniqueness. Japan has the longest life expectancy in the world, and Okinawa has the highest percentage of centenarians in the world, with about 50 centenarians out of 100,000 people.
Professor Li focuses on the interaction between probiotics and human microbiota. He designed an experiment in which more than 100 participants ate Lactobacillus casei, a probiotic bacterium that helps prevent and treat digestive diseases, and then monitors their body's reactions.
The Asian International Nutrition and Health Food Fair will be held at the Golden Sand Convention and Exhibition Center on September 11-12, 2018. Dr. Ideas and Professor Li will give a speech on their latest research findings.
The annual conference is the only international professional event that covers nutritional and health foods, which refer to dietary products that help prevent or treat diseases, from raw materials to finished products. More than 300 vendors from around the world will attend this year's exhibition, including raw material manufacturers such as AtoGen and Probiotics EF-2001 manufacturer BeRM INTERNATIONAL.
Learning from centenarians
The theme of Dr. Ideas's speech was "Finding Healthy New Anti-aging Methods from the Microbial Compositions of Centenarians". Speaking of his research, Dr. Ideas said: "We're going to reverse the aging process of centenarians to improve nutritional products in the future, and we can add some similar microorganisms that can help people live healthier lives or get older."
He found an alpha bacterium called Akkermania muciniphila in the gut of centenarians in Okinawa. It can produce acetate, which can promote fat consumption.
"We can reproduce this acetate by fermenting soybeans and then let people eat it, and it might be difficult to survive in the human gut if we use Actinia directly. In this way, we can maximize the effective use of this probiotic. " Dr. Ideas explained.
To develop more effective nutritional products, Dr. Ideals has developed a biofermentation system that mimics human parameters or body temperature. "We can mimic human fermentation of fruits and plants, and we can develop metabolites similar to those in centenarians by screening for the microorganisms we need," he said.
Dr Ideals went on to say, "So far, we have successfully extracted a variety of molecules, including hundreds of metabolites, which we standardized using automated high performance liquid chromatography systems. Biologically fermented metabolites are also better than non-fermented molecules because they are more active and synergistic. "
Professor Li will deliver a speech entitled "Developing personalized probiotic products for Asians and their lifestyles". "This customization is necessary because the choice and effectiveness of probiotic products depend on people's diet, health and living conditions," he said.
Professor Li found that the microbial community in the gut of the subjects changed after eating probiotics containing Lactobacillus casei, but because each individual's own microbial population is different, so the changes are not the same.
Professor Li said that scientific and clinical data showed that diet plays an important role in shaping human intestinal microflora, so the customization of probiotic products should take into account dietary differences.
He pointed out: "Compared with Europeans or Americans, Asians have very different eating habits and living conditions. Even in Asia, there are different dietary and living conditions in different places. In India, for example, the eating habits of northerners and southerners are different. "
So Professor Li believes that "because of this, probiotic products should be customized according to dietary habits, health status, living conditions and expected results rather than geographical location. Bacteroides and bifidobacteria, for example, help prevent infectious diseases and mental disorders, while Lactobacillus generally helps reduce the incidence of lactose intolerance.
September 21, 2018
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