Curcumin - A Dynamic Station For Metabolic Health
- Jan 26, 2018 -

4 weeks of 2018

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When it comes to popular herbs, turmeric is the first thing to be known. Turmeric is known as a top anti-inflammatory plant. In recent years, with the study of Jiang Huang (curcumin), its popularity in consumers has increased year by year, and has been applied to a large number of products. Starting from its multiple uses in Ayurveda, the traditional health effects of turmeric are now being scientifically verified. The advantages of Curcuma include promoting cardiovascular health, brain health, joint and liver health, and so on. But in a series of forms of bioavailability, scientists are still scratping their heads.

In addition to the health benefits of curcumin mentioned earlier, the other health effects of curcumin and curcumin are not well known; for example, their role in maintaining blood sugar health has been confirmed by some research. According to the survey data, about 30000000 people in the United States are suffering from diabetes, and another 84 million have diabetes. Under such circumstances, the need for a safe and effective alternative to diabetes is obvious.

Some studies have shown that Jiang Huang has a positive effect on parameters related to metabolic function. For example, a meta-analysis and randomized controlled trial was conducted by researchers from the Federal Institute of technology in Brazil to assess the effects of Jiang Huang extract on blood glucose regulation. The meta-analysis included 11 trials, and the subjects in the randomized controlled trial were adults aged 18 or above. The main outcome measures included changes in fasting blood glucose levels, followed by changes in hemoglobin A1c (HbA1c) and insulin resistance.

The results of meta-analysis showed that the level of HbA1c decreased significantly and fasting blood glucose decreased in the experimental group, but no significant change was found in HOMA-IR. HOMA-IR is an indicator of insulin resistance. Interestingly, it is most effective in those with a certain degree of blood glucose imbalance, including those with diabetes, to supplement the single curcumin or compound curcumin, which suggests that curcumin is more effective in those with higher blood sugar levels. This study confirms that turmeric extract can play an important role in the treatment of diabetes.

Enhancement of fatty acid metabolism

A team of researchers at Harbin Medical University tried to find out the mechanism of curcumin lowering blood sugar levels. In previous animal studies, the researchers found that curcumin reduced the level of free fatty acids in the serum and increased the level of blood sugar by increasing the lipid oxidation of muscle tissue, and improved insulin resistance. The human clinical research is to determine whether these effects can also be established in diabetic patients.

The researchers recruited a number of overweight diabetic patients, divided into two groups, a group of 300 milligrams of curcumin a day, and a group of placebo, for a period of 3 months. Finally, a total of 100 participants completed the experiment.

The results showed that supplemental substances containing curcumin could lead to a significant decrease in fasting blood glucose and insulin resistance, while significantly reducing the total free fatty acids and triglycerides in the serum. At the same time, the activity of enzyme also increases. Lipoprotein lipase can decompose triglycerides into free fatty acids. Therefore, an important mechanism of curcumin in human body may be to reduce the level of fasting blood glucose by promoting the oxidation and utilization of fatty acids.

Improving adiponectin: leptin ratio

Previous studies have found that curcumin is good for those who experience insulin resistance. Researchers from Iran's Tehran University of Ba ara Medical University investigated the interaction between curcumin and adiponectin and leptin in a study in 2016. It is well known that adiponectin can regulate insulin sensitivity, and leptin is a component that inhibits appetite, stimulates heat, increases fatty acid oxidation, and reduces body fat in glucose and obesity. The researchers found that increasing the ratio of adiponectin to leptin is beneficial to healthy insulin function.

In a randomized placebo-controlled trial, patients with metabolic syndrome were asked to receive 1000 mg of curcumin daily for 8 weeks. The levels of adiponectin and leptin in the serum of the subjects were measured after the study. Finally, the researchers found that curcumin is associated with a significant increase in serum adiponectin and the decrease of serum leptin levels, which is a potential mechanism for curcumin to support healthy insulin sensitivity.

Antioxidation and anti-inflammatory properties

Curcumin is known for its antioxidant and anti-inflammatory effects. These mechanisms may help alleviate metabolic syndrome. Researchers in Egypt have recently studied the effects of curcumin on mice with albinism, trying to determine the role of curcumin in the antioxidant and anti-inflammatory processes of metabolic syndrome.

During the study, researchers fed rats with high-fat foods to induce metabolic syndrome. After that, the rats were randomly divided into two groups, one group was fed curcumin (200 mg / kg body weight per day), the other group was given a placebo for 8 weeks. During the trial, the researchers evaluated the rats' weight, blood pressure, insulin resistance, serum glucose level, insulin level, leptin level, blood lipid level, malondialdehyde (lipid peroxidation product) levels, serum catalase (antioxidant) levels, and inflammatory markers (including NF-KB and TNF- alpha). The results showed that there were several significant negative changes in these metabolic parameters in the control group, but all the glucose in the experimental group were all glucose.

January 26, 2018