23 weeks of 2018
Recently, a study published in the Journal of marine medicine pointed out that edible seaweed can serve as a promising functional ingredient to resist hypertension and maintain weight. Researchers are known to investigate a variety of algae, including red algae (Rhodophyta), green algae (Chorophyta) and brown algae (Phaeophyta).
China, Japan and South Korea have always used algae as a traditional food. In recent years, with the global blend of national food, seaweed has also appeared on the European and American dining table. Seaweed can become the "top guest" of the table, and has its advantages, including lowering cardiovascular disease and prolonging the life span of the human body.
1. ACE 1 inhibitor substitutes
ACE1 inhibitors (ACE1 inhibitors) are a special family of drugs that can alleviate hypertension by inhibiting ACE1. But the drug has one drawback, which is side effects, including dry cough and swelling of certain tissues, including the throat. As a result of these side effects, researchers plan to use other components to inhibit the renin-angiotensin system (RAS) in the hypertensive proteogen (renin) activity.
It happens that some of the ingredients extracted from seaweed can play the role. It can inhibit RAS without side effects of ACE 1. The researchers revealed that polypeptides found in Undaria pinnatifida and Porphyra yezoensis have this effect, especially IY and AKYSY.
In addition, various brown algae polyphenols and polysaccharides found in seaweed also have significant antihypertensive effects. Among the various brown alga polyphenols, the researchers praised two 6,6, two A and Coptis chinensis. Among the seaweed polysaccharides, the researchers praised the marine polysaccharide (DPS), a mixture of carbohydrates that can be obtained from marine algae (pelvetiacanaliculata).
2. anti obesity metabolites
The researchers point out that the anti obesity components in seaweed are excellent carotenoids. As the star component of the algae metabolites, the bioefficacy of the alga flavin has been deeply studied by scientists; in all its physiological functions, the anti obesity effect has been studied most.
Specific algal polyphenols also play an important role in anti obesity, especially in the process of fat differentiation, which can be transformed into adipose tissue. In one study, the researchers found that the lower the molecular gravity of the brown algae polyphenols, the more significant its effect on the fat differentiation; the brown algae polyphenols, garcinol, two oxygen dehydrogenase and goose paedrol, extracted from the genus brown algae, have significant biological activity.
3. more biological research is needed
The researchers say the functional components of seaweed have shown great potential, but most of the related studies are conducted in a test tube, so more biological research data are needed. The researchers concluded that there is no doubt that the pure two grade metabolites of seaweed exhibit great antihypertensive and anti obesity potential, and have reached the concentration of inhibitor IC50 (which will inhibit the concentration of the inhibitor concentration required for the angiotensin converting enzyme activity of 50%, defined as IC50). IY and AKYSY (IC 501.52-2.96 uM) were the most ACE inhibitory components in algae, and berberyl alcohol A (IC 50 12.74 uM) was the most inhibitory polyphenol. Researchers have also published the role of algae components in the RAS system and nitric oxide synthesis, but further confirmation is needed.
Although the study was published in the Journal Pharmaceuticals, the researchers say it may be more widely used in the field of dietary supplements in the future. Importantly, many seaweeds that contain antihypertensive and anti-obesity active ingredients have been proven edible by scientists. Therefore, these ingredients are more likely to be first served in functional foods and then drugs.
June 8, 2018
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